ljb replied: "I was prescribed Prometrium at some point during my treatments for recurrent pregnancy loss -- I took it vaginally, 3x/day (originally 2x/day, but upped based on tested progesterone levels during treatment). I believe it was 200mg 3x/day but I can't be certain without checking my records. For each cycle during which I took Prometrium, I started taking it three days after ovulation, presumably (conjecture on my part) because three days of elevated BBTs are considered "confirmation" of ovulation, and you don't want to start taking any progesterone supps too early in the cycle. DId it help? Who can say? That's not an attempt to be snide, believe me. The medical studies are inconclusive -- at best -- and I certainly don't claim to know any better. Did I continue to -- eventually -- have a successful pregnancy? Yes. But whether the use of progesterone supplementation was a factor is anyone's guess. That said, as for MY guess: no, I've come to believe it doesn't really help. I've found there are essentially two schools of thought when it comes to progesterone issues, and, consequently, two different approaches to treatment. One: low progesterone levels are a problem in and of themselves, and treating that problem can help reduce the risk of subsequent pregnancy loss. Two: low progesterone levels are merely a symptom of a problem that occurred/occurs during the follicular phase of your cycle, and as far as the connection between low progesterone and pregnancy loss, it's more likely that low progesterone occurs as a result of a non-viable pregnancy, rather than that low progesterone causes the loss of an otherwise viable and healthy pregnancy. In talking with other women facing similar issues I found that more and more doctors (reproductive endocrinologists) were looking at ways to "boost" ovulation rather than directly treating progesterone levels -- *however* while the medical research has thus far failed to really support the hypothesis that supplementation helps prevent loss of an otherwise healthy pregnancy there is nothing out there that would suggest it can in any way cause harm, so many doctors do (or will, if asked) continue to prescribe supplementation on a more or less "just in case" basis. Sorry to be so run-on, but when asked whether Prometrium helped me....this is my honest answer to that question! As for the rest of it: I probably started the Prometrium when I was 36....maybe 35. (Amazing that I now cannot pull the exact date out of my head!) I used it for several cycles -- some natural cycles, others medicated. As for the latter, I never used Prometrium in conjunction with Clomid for the simple reason that Clomid did not work for me, and while I did ovulate on my own I did not ovulate when I tried Clomid. I did use Prometrium in conjunction with injectables. Eventually I moved on to more invasive treatments and no Prometrium was warranted because I experienced the dubious pleasures of progesterone by IM injection. As far as the creams go, it has been a bit of time since I read up on all of this stuff, but there are different "kinds" of progesterone supplements out there, to say nothing of the very different absorption issues depending on how the supp is administered, and if progesterone levels were truly an issue I personally would not take the creams, whether they were OTC herbal homeopathic creams or, if such a thing exists, a more "western" "medical" form that's simply administered as a cream. But then, I wouldn't even take the Prometrium orally, when the absorption rates for vaginal administration are so superior. I don't believe there is any way to say whether taking Prometrium "really prevent[ed] a suspected miscarriage," but who knows. It can't hurt, as far as I"m concerned. As indicated, I had a lot of treatments and they were certainly more invasive than Prometrium pills put in a very private place(!) but yes, all of that did work and I am now a very tired, very happy, mom of two. I hope that helps. There are some really helpful message boards out there where you might find other women with loads of experience and opinions on this issue, and other related issues -- I highly recommend the fertility forums at (and also which is not limited to women underoing IVF). Hope that helps, and BEST of luck. ETA I should have noted in the first place, I had some losses before Prometrium was introduced, but I also had losses when I was taking the Prometrium. So in that regard it's accurate to say that the Prometrium did not prevent miscarriage (although that's not what any doctor would tell you it does anyway!)."

Mommy to be Sept 09! replied: "I was on prometruim to start my periods since my periods were irregular not to get pregnant. I ended up pregnant 6 months later. GOOD LUCK!"